Gut microbial dysbiosis is associated with allergen-specific IgE responses in young children with airway allergies.

ABSTRACT:

Background

There is increasing evidence linking alterations of the gut microbial composition during early infancy to the development of atopic diseases and asthma. However, few studies have addressed the association of dysbiotic gut microbiota with allergic reactions through evaluation of feces in young children with allergic airway diseases.

Methods

We sought to evaluate relationships among gut microbiota, total fecal immunoglobulin E (IgE) levels, serum allergic sensitization, and their relevance to childhood allergic rhinitis and asthma. Microbial composition and diversity were analyzed with Illumina-based 16S rRNA gene sequencing of 89 stool samples collected from children with asthma (n = 35) and allergic rhinitis (n = 28), and from healthy controls (n = 26). Data analy

SUBMITTER: Chiu CY 

PROVIDER: S-EPMC6439417 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature