Nanoneedle-Mediated Stimulation of Cell Mechanotransduction Machinery.

ABSTRACT: Biomaterial substrates can be engineered to present topographical signals to cells which, through interactions between the material and active components of the cell membrane, regulate key cellular processes and guide cell fate decisions. However, targeting mechanoresponsive elements that reside within the intracellular domain is a concept that has only recently emerged. Here, we show that mesoporous silicon nanoneedle arrays interact simultaneously with the cell membrane, cytoskeleton, and nucleus of primary human cells, generating distinct responses at each of these cellular compartments. Specifically, nanoneedles inhibit focal adhesion maturation at the membrane, reduce tension in the cytoskeleton, and lead to remodeling of the nuclear envelope at sites of impingement. The combined chan

SUBMITTER: Hansel CS 

PROVIDER: S-EPMC6439438 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature