Bioinspired Fabrication of DNA-Inorganic Hybrid Composites Using Synthetic DNA.

ABSTRACT: Nucleic acid nanostructures have attracted significant interest as potential therapeutic and diagnostic platforms due to their intrinsic biocompatibility and biodegradability, structural and functional diversity, and compatibility with various chemistries for modification and stabilization. Among the fabrication approaches for such structures, the rolling circle techniques have emerged as particularly promising, producing morphologically round, flower-shaped nucleic acid particles: typically hybrid composites of long nucleic acid strands and inorganic magnesium pyrophosphate (Mg₂PPi). These constructs are known to form via anisotropic nucleic acid-driven crystallization in a sequence-independent manner, rendering monodisperse and densely packed RNA or DNA-inorganic composites. H

SUBMITTER: Kim E 

PROVIDER: S-EPMC6439439 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature