Transcriptional profiles reveal a stepwise developmental program of memory CD8(+) T cell differentiation.

ABSTRACT: The generation of CD8(+) T-cell memory is a major aim of vaccination. While distinct subsets of CD8(+) T-cells are generated following immunization that differ in their ability to confer long-term immunity against infection, the transcriptional profiles of these subsets within endogenous vaccine-induced CD8(+) T cell responses have not been resolved. Here, we measure global transcriptional profiles of endogenous effector (TEFF), effector memory (TEM) and central memory (TCM) CD8(+) T-cells arising from immunization with three distinct prime-boost vaccine regimens. While a proportion of transcripts were uniquely regulated within distinct CD8(+) T cell populations, we observed progressive up- or down-regulation in the expression of a majority of differentially expressed transcripts when subs

SUBMITTER: Roychoudhuri R 

PROVIDER: S-EPMC6439469 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature