Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial.

ABSTRACT:

Importance

There are currently no proven treatments to reduce the risk of mild cognitive impairment and dementia.

Objective

To evaluate the effect of intensive blood pressure control on risk of dementia.

Design, setting, and participants

Randomized clinical trial conducted at 102 sites in the United States and Puerto Rico among adults aged 50 years or older with hypertension but without diabetes or history of stroke. Randomization began on November 8, 2010. The trial was stopped early for benefit on its primary outcome (a composite of cardiovascular events) and all-cause mortality on August 20, 2015. The final date for follow-up of cognitive outcomes was July 22, 2018.

Interventions

Participants were randomized to a systolic blood pressure goal of either less t

SUBMITTER: SPRINT MIND Investigators for the SPRINT Research Group 

PROVIDER: S-EPMC6439590 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature