Effect of Combination of Paracetamol (Acetaminophen) and Ibuprofen vs Either Alone on Patient-Controlled Morphine Consumption in the First 24 Hours After Total Hip Arthroplasty: The PANSAID Randomized Clinical Trial.

ABSTRACT:

Importance

Multimodal postoperative analgesia is widely used but lacks evidence of benefit.

Objective

Investigate beneficial and harmful effects of 4 nonopioid analgesics regimens.

Design, setting, and participants

Randomized, blinded, placebo-controlled, 4-group trial in 6 Danish hospitals with 90-day follow-up that included 556 patients undergoing total hip arthroplasty (THA) from December 2015 to October 2017. Final date of follow-up was January 1, 2018.

Interventions

Participants were randomized to receive paracetamol (acetaminophen) 1000 mg plus ibuprofen 400 mg (n = 136; PCM + IBU), paracetamol 1000 mg plus matched placebo (n = 142; PCM), ibuprofen 400 mg plus matched placebo (n = 141; IBU), or half-strength paracetamol 500 mg plus ibuprofen 200 mg (n = 1

SUBMITTER: Thybo KH 

PROVIDER: S-EPMC6439592 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature