Effect of Electroencephalography-Guided Anesthetic Administration on Postoperative Delirium Among Older Adults Undergoing Major Surgery: The ENGAGES Randomized Clinical Trial.

ABSTRACT:

Importance

Intraoperative electroencephalogram (EEG) waveform suppression, often suggesting excessive general anesthesia, has been associated with postoperative delirium.

Objective

To assess whether EEG-guided anesthetic administration decreases the incidence of postoperative delirium.

Design, setting, and participants

Randomized clinical trial of 1232 adults aged 60 years and older undergoing major surgery and receiving general anesthesia at Barnes-Jewish Hospital in St Louis. Recruitment was from January 2015 to May 2018, with follow-up until July 2018.

Interventions

Patients were randomized 1:1 (stratified by cardiac vs noncardiac surgery and positive vs negative recent fall history) to receive EEG-guided anesthetic administration (n = 614) or usual anesthet

SUBMITTER: Wildes TS 

PROVIDER: S-EPMC6439616 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature