Association of Tramadol With All-Cause Mortality Among Patients With Osteoarthritis.

ABSTRACT:

Importance

An American Academy of Orthopaedic Surgeons guideline recommends tramadol for patients with knee osteoarthritis, and an American College of Rheumatology guideline conditionally recommends tramadol as first-line therapy for patients with knee osteoarthritis, along with nonsteroidal anti-inflammatory drugs.

Objective

To examine the association of tramadol prescription with all-cause mortality among patients with osteoarthritis.

Design, setting, and participants

Sequential, propensity score-matched cohort study at a general practice in the United Kingdom. Individuals aged at least 50 years with a diagnosis of osteoarthritis in the Health Improvement Network database from January 2000 to December 2015, with follow-up to December 2016.

Exposures

Initial p

SUBMITTER: Zeng C 

PROVIDER: S-EPMC6439672 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature