Association of Aspirin Use for Primary Prevention With Cardiovascular Events and Bleeding Events: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

The role for aspirin in cardiovascular primary prevention remains controversial, with potential benefits limited by an increased bleeding risk.

Objective

To assess the association of aspirin use for primary prevention with cardiovascular events and bleeding.

Data sources

PubMed and Embase were searched on Cochrane Library Central Register of Controlled Trials from the earliest available date through November 1, 2018.

Study selection

Randomized clinical trials enrolling at least 1000 participants with no known cardiovascular disease and a follow-up of at least 12 months were included. Included studies compared aspirin use with no aspirin (placebo or no treatment).

Data extraction and synthesis

Data were screened and extracted independently by b

SUBMITTER: Zheng SL 

PROVIDER: S-EPMC6439678 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature