Assessment of Racial Disparities in Biomarkers for Alzheimer Disease.

ABSTRACT:

Importance

Racial differences in molecular biomarkers for Alzheimer disease may suggest race-dependent biological mechanisms.

Objective

To ascertain whether there are racial disparities in molecular biomarkers for Alzheimer disease.

Design, setting, and participants

A total of 1255 participants (173 African Americans) were enrolled from January 1, 2004, through December 31, 2015, in longitudinal studies at the Knight Alzheimer Disease Research Center at Washington University and completed a magnetic resonance imaging study of the brain and/or positron emission tomography of the brain with Pittsburgh compound B (radioligand for aggregated amyloid-β) and/or cerebrospinal fluid (CSF) assays for the concentrations of amyloid-β42, total tau, and phosphorylated tau181. Inde

SUBMITTER: Morris JC 

PROVIDER: S-EPMC6439726 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature