Association of Genetic Risk Factors for Psychiatric Disorders and Traits of These Disorders in a Swedish Population Twin Sample.

ABSTRACT:

Importance

Psychiatric traits associated with categorically defined psychiatric disorders are heritable and present to varying degrees in the general population. It is commonly assumed that diagnoses represent the extreme end of continuously distributed traits in the population, but this assumption has yet to be robustly tested for many psychiatric phenotypes.

Objective

To assess whether genetic risk factors associated with psychiatric disorders are also associated with continuous variation in milder population traits.

Design, setting, and participants

This study combined a novel twin analytic approach with polygenic risk score (PRS) analyses in a large population-based twin sample. Phenotypic and genetic data were available from the Child and Adolescent Twin Study in

SUBMITTER: Taylor MJ 

PROVIDER: S-EPMC6439816 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature