Characterizing Developmental Trajectories and the Role of Neuropsychiatric Genetic Risk Variants in Early-Onset Depression.

ABSTRACT:

Importance

Depression often first manifests in adolescence. Thereafter, individual trajectories vary substantially, but it is not known what shapes depression trajectories in youth. Adult studies suggest that genetic risk for schizophrenia, a psychiatric disorder with a neurodevelopmental component, may contribute to an earlier onset of depression.

Objective

To test the hypothesis that there are distinct trajectories of depressive symptoms and that genetic liability for neurodevelopmental psychiatric disorders (eg, schizophrenia, attention deficit/hyperactivity disorder [ADHD]), as well as for major depressive disorder (MDD), contribute to early-onset depression.

Design, setting, and participants

The Avon Longitudinal Study of Parents and Children is an ongoing, prosp

SUBMITTER: Rice F 

PROVIDER: S-EPMC6439821 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature