Cognitive Performance in First-Degree Relatives of Individuals With vs Without Major Depressive Disorder: A Meta-analysis.

ABSTRACT:

Importance

Findings of cognitive impairment in major depressive disorder (MDD), including remitted MDD, raise the question whether impaired cognition is part of preexisting vulnerability rather than a consequence of MDD or its treatment. To our knowledge, no meta-analyses have been published on cognitive impairment in first-degree relatives of individuals with MDD.

Objective

To compare cognitive performance between individuals with and without family history of MDD.

Data sources

Medline/PubMed, PsycINFO, and Embase using combinations of search terms for depression, first-degree relatives, and cognition from January 1, 1980, to July 15, 2018.

Study selection

Original articles that reported data on cognition in first-degree relatives of individuals with MDD compa

SUBMITTER: MacKenzie LE 

PROVIDER: S-EPMC6439825 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature