Effect of Cricoid Pressure Compared With a Sham Procedure in the Rapid Sequence Induction of Anesthesia: The IRIS Randomized Clinical Trial.

ABSTRACT:

Importance

The use of cricoid pressure (Sellick maneuver) during rapid sequence induction (RSI) of anesthesia remains controversial in the absence of a large randomized trial.

Objective

To test the hypothesis that the incidence of pulmonary aspiration is not increased when cricoid pressure is not performed.

Design, setting, and participants

Randomized, double-blind, noninferiority trial conducted in 10 academic centers. Patients undergoing anesthesia with RSI were enrolled from February 2014 until February 2017 and followed up for 28 days or until hospital discharge (last follow-up, February 8, 2017).

Interventions

Patients were assigned to a cricoid pressure (Sellick group) or a sham procedure group.

Main outcomes and measures

Primary end point was the

SUBMITTER: Birenbaum A 

PROVIDER: S-EPMC6439856 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature