Radioguided Surgery With Gallium 68 Dotatate for Patients With Neuroendocrine Tumors.

ABSTRACT:

Importance

Neuroendocrine tumors (NETs) express somatostatin receptors, which can be targeted with radiolabeled peptides. In a variety of solid tumors, radioguided surgery (RGS) has been used to guide surgical resection. Gallium 68 (68Ga) dota peptides have been shown to be more accurate than other radioisotopes for detecting NETs. A pilot study previously demonstrated the feasibility and safety of 68Ga-dotatate RGS for patients with NETs.

Objective

To evaluate what intraoperative techniques and thresholds define positive lesions that warrant resection during 68Ga-dotatate RGS.

Design, setting, and participants

This prospective cohort study, conducted between October 23, 2013, and February 14, 2018, included 44 patients with NETs who underwent 68Ga-dotatate RGS.

In

SUBMITTER: El Lakis M 

PROVIDER: S-EPMC6439858 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature