Association of Genetic Variants in NUDT15 With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease.

ABSTRACT:

Importance

Use of thiopurines may be limited by myelosuppression. TPMT pharmacogenetic testing identifies only 25% of at-risk patients of European ancestry. Among patients of East Asian ancestry, NUDT15 variants are associated with thiopurine-induced myelosuppression (TIM).

Objective

To identify genetic variants associated with TIM among patients of European ancestry with inflammatory bowel disease (IBD).

Design, setting, and participants

Case-control study of 491 patients affected by TIM and 679 thiopurine-tolerant unaffected patients who were recruited from 89 international sites between March 2012 and November 2015. Genome-wide association studies (GWAS) and exome-wide association studies (EWAS) were conducted in patients of European ancestry. The replication cohor

SUBMITTER: Walker GJ 

PROVIDER: S-EPMC6439872 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature