Pharmacological Treatments for Neonatal Abstinence Syndrome: A Systematic Review and Network Meta-analysis.

ABSTRACT:

Importance

Incidence of neonatal abstinence syndrome is rising rapidly, and optimal pharmacotherapy may meaningfully reduce length of treatment.

Objective

To compare pharmacological therapies for neonatal abstinence syndrome.

Data sources

Systematic review and network meta-analysis of Medline (1946-June 2018), Embase (1974-June 2018), Cochrane CENTRAL (1966-June 2018), Web of Science (1900-June 2018), and ClinicalTrials.gov (June 2018).

Study selection

Randomized clinical trials of pharmacological treatments for neonatal abstinence syndrome alone or in combination with adjuvant treatments. Abstract, title, and full-text screening were conducted independently by 2 reviewers (T.D. and C.G.).

Data extraction and synthesis

Data extraction was conducted indep

SUBMITTER: Disher T 

PROVIDER: S-EPMC6439896 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature