Effect of Catheter Ablation vs Antiarrhythmic Medication on Quality of Life in Patients With Atrial Fibrillation: The CAPTAF Randomized Clinical Trial.

ABSTRACT:

Importance

Quality of life is not a standard primary outcome in ablation trials, even though symptoms drive the indication.

Objective

To assess quality of life with catheter ablation vs antiarrhythmic medication at 12 months in patients with atrial fibrillation.

Design, setting, and participants

Randomized clinical trial at 4 university hospitals in Sweden and 1 in Finland of 155 patients aged 30-70 years with more than 6 months of atrial fibrillation and treatment failure with 1 antiarrhythmic drug or β-blocker, with 4-year follow-up. Study dates were July 2008-September 2017. Major exclusions were ejection fraction <35%, left atrial diameter >60 mm, ventricular pacing dependency, and previous ablation.

Interventions

Pulmonary vein isolation ablation (n = 79)

SUBMITTER: Blomstrom-Lundqvist C 

PROVIDER: S-EPMC6439911 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature