Association of Dementia With Mortality Among Adults With Down Syndrome Older Than 35 Years.

ABSTRACT:

Importance

This work quantifies the fatal burden of dementia associated with Alzheimer disease in individuals with Down syndrome (DS).

Objective

To explore the association of dementia associated with Alzheimer disease with mortality and examine factors associated with dementia in adults with DS.

Design, settings and participants

Prospective longitudinal study in a community setting in England. Data collection began March 29, 2012. Cases were censored on December 13, 2017. The potential sample consisted of all adults 36 years and older from the London Down Syndrome Consortium cohort with 2 data times and dementia status recorded (N = 300); 6 withdrew from study, 28 were lost to follow-up, and 55 had a single data collection point at time of analysis. The final sample c

SUBMITTER: Hithersay R 

PROVIDER: S-EPMC6439956 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature