A new class of constitutively active super-enhancers is associated with fast recovery of 3D chromatin loops.

ABSTRACT:

Background

Super-enhancers or stretch enhancers are clusters of active enhancers that often coordinate cell-type specific gene regulation during development and differentiation. In addition, the enrichment of disease-associated single nucleotide polymorphism in super-enhancers indicates their critical function in disease-specific gene regulation. However, little is known about the function of super-enhancers beyond gene regulation.

Results

In this study, through a comprehensive analysis of super-enhancers in 30 human cell/tissue types, we identified a new class of super-enhancers which are constitutively active across most cell/tissue types. These 'common' super-enhancers are associated with universally highly expressed genes in contrast to the canonical definition of super-

SUBMITTER: Ryu J 

PROVIDER: S-EPMC6439976 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature