DNA Methylation Divergence and Tissue Specialization in the Developing Mouse Placenta.

ABSTRACT: The placental epigenome plays a vital role in regulating mammalian growth and development. Aberrations in placental DNA methylation are linked to several disease states, including intrauterine growth restriction and preeclampsia. Studying the evolution and development of the placental epigenome is critical to understanding the origin and progression of such diseases. Although high-resolution studies have found substantial variation between placental methylomes of different species, the nature of methylome variation has yet to be characterized within any individual species. We conducted a study of placental DNA methylation at high resolution in multiple strains and closely related species of house mice (Mus musculus musculus, Mus m. domesticus, and M. spretus), across developmental timepoin

SUBMITTER: Decato BE 

PROVIDER: S-EPMC6440273 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature