Di-O-lauroyl-decitabine-lipid nanocapsules: toward extending decitabine activity.

ABSTRACT:

Background

Acute myeloid leukemia mainly affects adult patients. Complete remission for patients younger than 60 years, who are candidates for standard induction therapy, is achieved in 60%-80% of cases. However, the prognosis is still poor for older patients, who are unfit for intensive chemotherapy, and only a few therapies are available. Hypomethylating agents, such as decitabine, are approved for such patients. The current dosing regimen consists of one administration per day, for 5 days, each 4 weeks.

Methods

Here, we present the synthesis of a decitabine prodrug, combined with its encapsulation into a lipid-based nanocapsule formulation. Decitabine (C12)₂ was synthetized, then loaded into nanocapsules. Its stability in phosphate buffer ans human plasma was c

SUBMITTER: Briot T 

PROVIDER: S-EPMC6440450 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature