Monomethyl Fumarate Protects the Retina From Light-Induced Retinopathy.

ABSTRACT:

Purpose

We determine if monomethyl fumarate (MMF) can protect the retina in mice subjected to light-induced retinopathy (LIR).

Methods

Albino BALB/c mice were intraperitoneally injected with 50 to 100 mg/kg MMF before or after exposure to bright white light (10,000 lux) for 1 hour. Seven days after light exposure, retinal structure and function were evaluated by optical coherence tomography (OCT) and electroretinography (ERG), respectively. Retinal histology also was performed to evaluate photoreceptor loss. Expression levels of Hcar2 and markers of microglia activation were measured by quantitative PCR (qPCR) in the neural retina with and without microglia depletion. At 24 hours after light exposure, retinal sections and whole mount retinas were stained with Iba1 to evaluat

SUBMITTER: Jiang D 

PROVIDER: S-EPMC6440526 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature