Isoniazid (INH) mono-resistance and tuberculosis (TB) treatment success: analysis of European surveillance data, 2002 to 2014.

ABSTRACT:

Introduction

Isoniazid (INH) is an essential drug for tuberculosis (TB) treatment. Resistance to INH may increase the likelihood of negative treatment outcome.

Aim

We aimed to determine the impact of INH mono-resistance on TB treatment outcome in the European Union/European Economic Area and to identify risk factors for unsuccessful outcome in cases with INH mono-resistant TB.

Methods

In this observational study, we retrospectively analysed TB cases that were diagnosed in 2002-14 and included in the European Surveillance System (TESSy). Multilevel logistic regression models were applied to identify risk factors and correct for clustering of cases within countries.

Results

A total of 187,370 susceptible and 7,578 INH mono-resistant TB cases from 24 countries wer

SUBMITTER: Karo B 

PROVIDER: S-EPMC6440580 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature