Source and Relevance of the BK Polyomavirus Genotype for Infection After Kidney Transplantation.

ABSTRACT:

Background

BK polyomavirus (BKPyV)-associated nephropathy (BKPyVAN) is a major threat for kidney transplant recipients (KTRs). The role of specific BKPyV genotypes/serotypes in development of BKPyVAN is poorly understood. Pretransplantation serotyping of kidney donors and recipients and posttransplantation genotyping of viremic recipients, could reveal the clinical relevance of specific BKPyV variants.

Methods

A retrospective cohort of 386 living kidney donor-recipient pairs was serotyped before transplantation against BKPyV genotype I-IV viral capsid protein 1 antigen, using a novel BKPyV serotyping assay. Replicating BKPyV isolates in viremic KTRs after transplantation were genotyped using real-time polymerase chain reaction and confirmed by means of sequencing. BKPyV sero

SUBMITTER: Wunderink HF 

PROVIDER: S-EPMC6440680 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature