The Influence of Microglial Elimination and Repopulation on Stress Sensitization Induced by Repeated Social Defeat.

ABSTRACT:

Background

Stress is associated with an increased prevalence of anxiety and depression. Repeated social defeat (RSD) stress in mice increases the release of monocytes from the bone marrow that are recruited to the brain by microglia. These monocytes enhance inflammatory signaling and augment anxiety. Moreover, RSD promotes stress sensitization, in which exposure to acute stress 24 days after cessation of RSD causes anxiety recurrence. The purpose of this study was to determine whether microglia were critical to stress sensitization and exhibited increased reactivity to subsequent acute stress or immune challenge.

Methods

Mice were exposed to RSD, microglia were eliminated by colony-stimulating factor 1 receptor antagonism (PLX5622) and allowed to repopulate, and responses to

SUBMITTER: Weber MD 

PROVIDER: S-EPMC6440809 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature