Genome-wide association analysis suggests novel loci underlying thyroid antibodies in Hashimoto's thyroiditis.

ABSTRACT: Thyroid antibodies against thyroglobulin (TgAb) and thyroid peroxidase (TPOAb) are key markers of Hashimoto's thyroiditis (HT), the most common autoimmune thyroid disorder. Genetic determinants of thyroid antibodies are still poorly known, especially as they were not studied in patients with thyroid diseases. We performed the first genome-wide association analysis of thyroid antibodies in 430 HT patients that may be considered as population extremes for thyroid antibodies distribution. We detected two suggestively associated genetic variants with TgAb, rs6972286 close to ANKRD7 and LSM8 (P = 2.34 × 10^-7) and rs756763 inside CA10 (P = 6.05 × 10^-7), and one with TPOAb, rs12507813 positioned between TRIM61 and TRIM60 (P = 4.95 × 10^-7). Bivariate analysis resul

SUBMITTER: Brcic L 

PROVIDER: S-EPMC6440971 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature