Electrotaxis of Glioblastoma and Medulloblastoma Spheroidal Aggregates.

ABSTRACT: Treatment of neuroepithelial cancers remains a daunting clinical challenge, particularly due to an inability to address rampant invasion deep into eloquent regions of the brain. Given the lack of access, and the dispersed nature of brain tumor cells, we explore the possibility of electric fields inducing directed tumor cell migration. In this study we investigate the properties of populations of brain cancer undergoing electrotaxis, a phenomenon whereby cells are directed to migrate under control of an electrical field. We investigate two cell lines for glioblastoma and medulloblastoma (U87mg & DAOY, respectively), plated as spheroidal aggregates in Matrigel-filled electrotaxis channels, and report opposing electrotactic responses. To further understand electrotactic migration of tumor cel

SUBMITTER: Lyon JG 

PROVIDER: S-EPMC6441013 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature