Monocytes/Macrophages play a pathogenic role in IL-23 mediated psoriasis-like skin inflammation.

ABSTRACT: Psoriasis is an immune-mediated inflammatory skin disease that affects millions worldwide. Studying immune cells involved in psoriasis pathogenesis is essential to identify effective and safe therapeutics for the disease. Using human psoriasis skin, activated macrophages were observed in both lesional and non-lesional skin, but were elevated in lesional skin. Activation of the IL-23/IL-17 pathway is integral to the development of psoriasis. To further characterize the monocyte/macrophage (Mon/Mac) population when the IL-23 pathway is activated, a murine model of intradermal injection of IL-23 was used. Flow cytometry revealed that Mon/Mac cells were the dominant immune population, particularly late in the model, highlighted by strong presence of Ly6C^hiMHC II^hi cells.

SUBMITTER: Wang Y 

PROVIDER: S-EPMC6441056 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature