Reduced Serum and Cerebrospinal Fluid Levels of Autotaxin in Major Depressive Disorder.

ABSTRACT:

Background

The autotaxin/lysophosphatidic acid axis is involved in diverse biological processes including neurodevelopment, inflammation, and immunological functioning. The lysophosphatidic acid 1 receptor has been implicated in the pathophysiology of major depressive disorder and in the mechanism of action of antidepressants. However, it is unclear whether central or peripheral autotaxin levels are altered in patients with major depressive disorder.

Methods

Serum autotaxin levels were measured by an enzyme-linked immunosorbent assay in 37 patients with major depressive disorder diagnosed using DSM-IV-TR who underwent electroconvulsive therapy and were compared with those of 47 nondepressed controls matched for age and sex between January 2011 and December 2015. Patient seru

SUBMITTER: Itagaki K 

PROVIDER: S-EPMC6441130 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature