Microvesicles and chemokines in tumor microenvironment: mediators of intercellular communications in tumor progression.

ABSTRACT: Increasing evidence indicates that the ability of cancer cells to convey biological information to recipient cells within the tumor microenvironment (TME) is crucial for tumor progression. Microvesicles (MVs) are heterogenous vesicles formed by budding of the cellular membrane, which are secreted in larger amounts by cancer cells than normal cells. Recently, several reports have also disclosed that MVs function as important mediators of intercellular communication between cancerous and stromal cells within the TME, orchestrating complex pathophysiological processes. Chemokines are a family of small inflammatory cytokines that are able to induce chemotaxis in responsive cells. MVs which selective incorporate chemokines as their molecular cargos may play important regulatory roles in oncogen

SUBMITTER: Bian X 

PROVIDER: S-EPMC6441155 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature