Exploiting vulnerabilities of cancer by targeting nuclear receptors of stromal cells in tumor microenvironment.

ABSTRACT: The tumor microenvironment is a complex and dynamic cellular community comprising the tumor epithelium and various tumor-supporting cells such as immune cells, fibroblasts, immunosuppressive cells, adipose cells, endothelial cells, and pericytes. The interplay between the tumor microenvironment and tumor cells represents a key contributor to immune evasiveness, physiological hardiness and the local and systemic invasiveness of malignant cells. Nuclear receptors are master regulators of physiological processes and are known to play pro-/anti-oncogenic activities in tumor cells. However, the actions of nuclear receptors in tumor-supporting cells have not been widely studied. Given the excellent druggability and extensive regulatory effects of nuclear receptors, understanding their biological

SUBMITTER: Cheng HS 

PROVIDER: S-EPMC6441226 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature