Kruppel-like factor 14, a coronary artery disease associated transcription factor, inhibits endothelial inflammation via NF-κB signaling pathway.

ABSTRACT:

Background and aims

Human genetic studies indicated that variations near the transcription factor Krüppel-like factor 14 (KLF14) gene locus are highly associated with coronary artery disease. Activation of endothelial cells (ECs) by pro-inflammatory molecules and pathways is a primary step in atherosclerosis development. We aimed to investigate the effects and mechanism of KLF14 on inflammatory responses in ECs.

Methods

Adenovirus-mediated overexpression of human KLF14 and EC specific Klf14 knockout mice were applied to study the role of KLF14 in EC inflammation. Intravital microscopy was used to examine leukocyte-endothelial cell interactions in vivo.

Results

The expression of Klf14 was markedly decreased in mouse aortic ECs in both acute and chronic inflammatory con

SUBMITTER: Hu W 

PROVIDER: S-EPMC6441279 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature