Sequential Payload Release from Acoustically-Responsive Scaffolds Using Focused Ultrasound.

ABSTRACT: Regenerative processes, such as angiogenesis and osteogenesis, often require multiple growth factors with distinct spatiotemporal patterns and expression sequences. Within tissue engineering, hydrogel scaffolds are commonly used for exogenous growth factor delivery. However, direct incorporation of growth factors within conventional hydrogels does not afford spatiotemporally controlled delivery because release is governed by passive mechanisms that cannot be actively controlled after the scaffold is implanted. We have developed acoustically-responsive scaffolds (ARSs), which are fibrin scaffolds doped with payload-containing, sonosensitive emulsions. Payload release from ARSs can be controlled non-invasively and on demand using focused, megahertz-range ultrasound. In the in vitro study des

SUBMITTER: Moncion A 

PROVIDER: S-EPMC6441330 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature