Tryptophan carbon dots and their ability to cross the blood-brain barrier.

ABSTRACT: Drug traversal across the blood-brain barrier has come under increasing scrutiny recently, particularly concerning the treatment of sicknesses, such as brain cancer and Alzheimer's disease. Most therapies and medicines are limited due to their inability to cross this barrier, reducing treatment options for maladies affecting the brain. Carbon dots show promise as drug carriers, but they experience the same limitations regarding crossing the blood-brain barrier as many small molecules do. If carbon dots can be prepared from a precursor that can cross the blood-brain barrier, there is a chance that the remaining original precursor molecule can attach to the carbon dot surface and lead the system into the brain. Herein, tryptophan carbon dots were synthesized with the strategy of using trypto

SUBMITTER: Mintz KJ 

PROVIDER: S-EPMC6441370 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature