Altered pharmacokinetics of combined oral contraceptives in obesity - multistudy assessment.

ABSTRACT:

Objective

The objective was to evaluate the pharmacokinetics (PKs) of levonorgestrel (LNG)-containing combined oral contraceptives (COCs) in obese women.

Study design

We pooled and reanalyzed data from 89 women with different body mass index (BMI) categories from four clinical studies. The LNG and ethinyl estradiol (EE) PKs were analyzed utilizing a zero-order absorption (K₀), two-compartment PK model to evaluate key PK parameters in relation to a range of weights, BMI and body surface area (BSA).

Results

Increasing of body habitus metrics is correlated with decreasing C_max (p<.0001) and AUC_τ (p<.05) for both LNG and EE, but no correlation was found for C_min (p≥.17). Increasing weight and BMI were associated with a modest in

SUBMITTER: Luo D 

PROVIDER: S-EPMC6441376 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature