Advances in domain and subunit localization technology for electron microscopy.

ABSTRACT: The award of the 2017 Nobel Prize in chemistry, 'for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution', was recognition that this method, and electron microscopy more generally, represent powerful techniques in the scientific armamentarium for atomic level structural assessment. Technical advances in equipment, software, and sample preparation, have allowed for high-resolution structural determination of a range of complex biological machinery such that the position of individual atoms within these mega-structures can be determined. However, not all targets are amenable to attaining such high-resolution structures and some may only be resolved at so-called intermediate resolutions. In these cases, other tools are needed to corr

SUBMITTER: Brown ZP 

PROVIDER: S-EPMC6441409 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature