A Six-Gene-Based Prognostic Model Predicts Survival in Head and Neck Squamous Cell Carcinoma Patients.

ABSTRACT:

Background and objective

Head and neck cancer is a malignant tumor that begins in the head and neck region, and has the sixth highest incidence worldwide. Previous studies have indicated several prognostic markers for head and neck squamous cell carcinoma (HNSCC), but due to poor accuracy and sensitivity of these clinical characteristic markers attention has been gradually switched to molecular biomarkers. This study aimed to sort out the mRNAs correlated with patient survival time to establish an mRNA combination prognostic biomarker model for HNSCC patient risk stratification, providing optimal therapeutic regimens and improving patient prognosis.

Methods

Clinical data and transcriptome sequencing data of HNSCC were retrieved from TCGA database and were allocated into trai

SUBMITTER: Pawar S 

PROVIDER: S-EPMC6441444 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature