Investigation of health benefits of cocoa in human colorectal cancer cell line, HT-29 through interactome analysis.

ABSTRACT:

Aim

This bioinformatics study aims to identify the potential key genes influenced by cocoa extraction treatment on colon cancer cell line HT-29 after 24h.

Background

Cocoa consumption has been claimed to have beneficial effects on human body including protection against diseases such as different types of cancers. However, the mechanisms behind this is still remained to be studied.

Methods

The microarray dataset (GSE94154) from GEO, was the source for differentially expressed genes (DEGs) extraction through GEO2R analysis. The comparison was between 3 controls of colorectal cell line HT-29 and 3 ones incubated with 500 µg cocoa extraction after 24 h. Afterwards, the top significant DEGs were assigned for protein-protein interaction network construction and analysis by

SUBMITTER: Zamanian-Azodi M 

PROVIDER: S-EPMC6441487 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature