Sequence and expression levels of circular RNAs in progenitor cell types during mouse corticogenesis.

ABSTRACT: Circular (circ) RNAs have recently emerged as a novel class of transcripts whose identification and function remain elusive. Among many tissues and species, the mammalian brain is the organ in which circRNAs are more abundant and first evidence of their functional significance started to emerge. Yet, even within this well-studied organ, annotation of circRNAs remains fragmentary, their sequence is unknown, and their expression in specific cell types was never investigated. Overcoming these limitations, here we provide the first comprehensive identification of circRNAs and assessment of their expression patterns in proliferating neural stem cells, neurogenic progenitors, and newborn neurons of the developing mouse cortex. Extending the current knowledge about the diversity of this class of

SUBMITTER: Dori M 

PROVIDER: S-EPMC6441494 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature