Relative Contributions of Intracranial Pressure and Intraocular Pressure on Lamina Cribrosa Behavior.

ABSTRACT:

Purpose

To characterize the relative contributions of intraocular pressure (IOP) and intracranial pressure (ICP) on lamina cribrosa (LC) behavior, specifically LC depth (LCD) and LC peak strain.

Methods

An axially symmetric finite element model of the posterior eye was constructed with an elongated optic nerve and retro-orbital subarachnoid space ensheathed by pia and dura mater. The mechanical environment in LC was evaluated with ICP ranging from 5 to 15 mmHg and IOP from 10 to 45 mmHg. LCD and LC peak strains at various ICP and IOP levels were estimated using full factorial experiments. Multiple linear regression analyses were then applied to estimate LCD and LC peak strain using ICP and IOP as independent variables.

Results

Both increased ICP and decreased IOP led

SUBMITTER: Tong J 

PROVIDER: S-EPMC6441528 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature