Interactions between Germline and Somatic Mutated Genes in Aggressive Prostate Cancer.

ABSTRACT: Prostate cancer (PCa) is the most common diagnosed malignancy and the second leading cause of cancer-related deaths among men in the USA. Advances in high-throughput genotyping and next generation sequencing technologies have enabled discovery of germline genetic susceptibility variants and somatic mutations acquired during tumor formation. Emerging evidence indicates that germline variations may interact with somatic events in carcinogenesis. However, the possible oncogenic interactions and cooperation between germline and somatic variation and their role in aggressive PCa remain largely unexplored. Here we investigated the possible oncogenic interactions and cooperation between genes containing germline variation from genome-wide association studies (GWAS) and genes containing somatic mu

SUBMITTER: Mamidi TKK 

PROVIDER: S-EPMC6441536 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature