Effect of Propofol on the Production of Inflammatory Cytokines by Human Polarized Macrophages.

ABSTRACT: Macrophages are key immune system cells involved in inflammatory processes. Classically activated (M1) macrophages are characterized by strong antimicrobicidal properties, whereas alternatively activated (M2) macrophages are involved in wound healing. Severe inflammation can induce postoperative complications during the perioperative period. Invasive surgical procedures induce polarization to M1 macrophages and associated complications. As perioperative management, it is an important strategy to regulate polarization and functions of macrophages during inflammatory processes. Although propofol has been found to exhibit anti-inflammatory activities in monocytes and macrophages, it is unclear whether propofol regulates the functions of M1 and M2 macrophages during inflammatory processes. Thi

SUBMITTER: Kochiyama T 

PROVIDER: S-EPMC6441544 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature