Evaluation of a toxoid fusion protein vaccine produced in plants to protect poultry against necrotic enteritis.

ABSTRACT:

Background

Necrotic enteritis (NE) is caused by type A strains of the bacterium Clostridium perfringens. Total global economic losses to the poultry industry due to NE is estimated to be over two billion dollars annually. Traditionally, NE has been effectively controlled by inclusion of antibiotics in the diet of poultry. However, recent concerns regarding the impact of this practice on increasing antibiotic resistance in human pathogens have led us to consider alternative approaches, such as vaccination, for controlling this disease. NE strains of C. perfringens produce two major toxins, a-toxin and NetB. Immune responses against either toxin can provide partial protection against NE.

Methods

We have developed a fusion protein combining a non-toxic carboxyl-te

SUBMITTER: Hunter JGL 

PROVIDER: S-EPMC6441560 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature