Impacts of air pollution, temperature, and relative humidity on leukocyte distribution: An epigenetic perspective.

ABSTRACT: BACKGROUND:Exploring the associations of air pollution and weather variables with blood leukocyte distribution is critical to understand the impacts of environmental exposures on the human immune system. OBJECTIVES:As previous analyses have been mainly based on data from cell counters, which might not be feasible in epidemiologic studies including large populations of long-stored blood samples, we aimed to expand the understanding of this topic by employing the leukocyte distribution estimated by DNA methylation profiles. METHODS:We measured DNA methylation profiles in blood samples using Illumina HumanMethylation450 BeadChip from 1519 visits of 774 Caucasian males participating in the Normative Aging Study. Leukocyte distribution was estimated using Houseman's and Horvath's algorithms. Da

SUBMITTER: Gao X 

PROVIDER: S-EPMC6441628 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature