Neutrophils Restrict Tumor-Associated Microbiota to Reduce Growth and Invasion of Colon Tumors in Mice.

ABSTRACT:

Background & aims

Neutrophils are among the most prevalent immune cells in the microenvironment of colon tumors; they are believed to promote growth of colon tumors, and their numbers correlate with outcomes of patients with colon cancer. Trials of inhibitors of neutrophil trafficking are underway in patients with cancer, but it is not clear how neutrophils contribute to colon tumorigenesis.

Methods

Colitis-associated colon cancer was induced in mice with conditional deletion of neutrophils (LysMCre;Mcl1^fl/fl) and wild-type littermates (LysMCre;Mcl1^wt/wt, control mice) by administration of azoxythmethane and/or dextran sulfate sodium. Sporadic colon tumorigenesis was assessed in neutrophil-deficient and neutrophil-replete mice with conditional deletion

SUBMITTER: Triner D 

PROVIDER: S-EPMC6441634 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature