Ontology highlight
ABSTRACT:
SUBMITTER: Kategaya L
PROVIDER: S-EPMC6441948 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
iScience 20190318
Werner syndrome protein (WRN) is a RecQ enzyme involved in the maintenance of genome integrity. Germline loss-of-function mutations in WRN led to premature aging and predisposition to cancer. We evaluated synthetic lethal (SL) interactions between WRN and another human RecQ helicase, BLM, with DNA damage response genes in cancer cell lines. We found that WRN was SL with a DNA mismatch repair protein MutL homolog 1, loss of which is associated with high microsatellite instability (MSI-H). MSI-H c ...[more]