Metabolomic correlates of aerobic capacity among elderly adults.

ABSTRACT:

Background

Aerobic capacity is a powerful predictor of cardiovascular disease and all-cause mortality, and it declines with advancing age.

Hypothesis

Since physical activity alters body metabolism, metabolism markers will likely differ between subjects with high vs low aerobic capacities.

Methods

Community-based participants without physician-diagnosed heart disease, stroke or cancer underwent same-day multimodal assessment of cardiovascular function (by echocardiography and magnetic resonance feature tracking of left atrium) and aerobic capacity by peak oxygen uptake (VO₂ ) metrics. Associations between VO₂ and cardiovascular and metabolomics profiles were studied in adjusted models including standard covariates.

Results

We studied 141 pa

SUBMITTER: Koh AS 

PROVIDER: S-EPMC6441956 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature