Enhanced Pharmacological Ascorbate Oxidation Radiosensitizes Pancreatic Cancer.

ABSTRACT: Pharmacologic ascorbate (P-AscH^-) is emerging as a promising adjuvant for advanced pancreatic cancer. P-AscH^- generates hydrogen peroxide (H₂O₂), leading to selective cancer cell cytotoxicity. Catalytic manganoporphyrins, such as MnT4MPyP, can increase the rate of oxidation of P-AscH^-, thereby increasing the flux of H₂O₂, resulting in increased cytotoxicity. We hypothesized that a multimodal treatment approach, utilizing a combination of P-AscH^-, ionizing radiation and MnT4MPyP, would result in significant flux of H₂O₂ and pancreatic cancer cytotoxicity. P-AscH^- with MnT4MPyP increased the rate of oxidation of P-AscH^- and produced radiosensitization in all pan

SUBMITTER: Alexander MS 

PROVIDER: S-EPMC6441967 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature