Effects of Phyllanthus amarus PHYLLPRO^TM leaves on hangover symptoms: a randomized, double-blind, placebo-controlled crossover study.

ABSTRACT:

Context

Phyllanthus amarus Schumach. and Thonn. (Euphorbiaceae) is traditionally known to improve general liver health. However, its effect on hangover is unknown.

Objective

This study evaluated PHYLLPRO™, a standardized ethanol extract of P. amarus leaves for protection against oxidative stress and recovery from hangover symptoms.

Material and methods

Ten days daily oral supplementation of 750 mg/day followed by intoxication was evaluated in a randomized placebo-controlled (containing only excipient), crossover study in 15 subjects (21-50 years old), for oxidative stress, liver damage, alleviating hangover symptoms (Hangover Severity Score: HSS) and mood improvement (Profile-of-Mood-Scores: POMS).

Results

PHYLLPRO™ was able to remove blood alcohol in the activ

SUBMITTER: George A 

PROVIDER: S-EPMC6442116 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature